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Although in the last few years Colombia has faced significant civil society mobilization, 2021 represented critical juncture in social mobilization that was the result of three converging crises. The COVID-19 pandemic, a health crisis, triggered an economic crisis that exacerbated existing social and economic inequalities. Together they aggravated a pre-existing governability crisis. Unions and other actors convened a national strike on April 28 and the violent police response ignited the protest. The strike lasted almost two months and framed the legislative and presidential elections in 2022. This paper analyzes these events, their effects, and the perspectives for the future.