As we reach the first half of President Juan Manuel Santos’ term (2010-2014), this article focuses on the process of reconfiguration of political forces that started in Colombia when he became President in 2010, and which came to fruition in 2012, with the definitive breakup with former President Uribe. We build on the idea that, after a period of confusion and political volatility, the country finally reached a situation where the adversaries as well as their social support can be distinguished more accurately. We analyze changes and ruptures occurred during this administration in terms of political and economic agenda, especially on issues such as changes in the party system, Santos’ relationship with Congress, the negotiations with FARC in the beginning of the peace process and economic growth associated with mining.